منابع مشابه
Studies on fluorinated pyrimidines. VIII. Further biochemical and metabolic investigations.
We have previously reported on the tumor inhibitory properties of 5-fluorouracil and 5-fluoroorotic acid (3, 4), prepared by Duschinsky et al. (5), and on the initial clinical trials of 5fluorouracil with patients with far advanced solid tumors (6). The metabolism of 5-fluorouracil and 5-fluororotic acid has been studied, data on excretion and tissue distribution in mice and man have been repor...
متن کاملX-ray studies on phospholipid bilayers. VIII. Interactions with chlorpromazine.HCl.
Chlorpromazine is a widely used phenothiazine tranquilizer known to alter the shape of normal erythrocytes and their osmotic fragility. In order to understand the nature of the interactions chlorpromazine.HCl (CPZ.HCl) was made to interact with phospholipid bilayers formed by dimyristoylphosphatidylethanolamine (DMPE) and dimyristoylphosphatidylcholine (DMPC). This study was carried out by X-ra...
متن کاملStudies on the Purification and Characterization of Human Factor VIII
The purified factor VIII has been found to be a macromolecular glycoprotein with a major subunit of 240,000, as shown by sodium dodecyl sulfate (SDS) polyacrylamide gel electrophoresis. Carbohydrate analysis of factor VIII gave values of 1% sialic acid, 2.8% hexosamine, and 1-2% hexose (mannose, galactose, and fucose). The lipid content was found to be less than 5% of the protein content, and i...
متن کاملMetalloprotein Design & Engineering
Metalloproteins play important roles in biology. They account for about 1/3 of structurally characterized proteins and about 1/2 of all proteins.1 The availability of different metal ions with various redox states, ligands, and geometries about the metal ion allows for fine-tuning of the reactivity of proteins at the highest level. As shown in other sections of this encyclopedia, studies of nat...
متن کاملDevelopment of supramolecular metalloprotein mimics
Supramolecular mimics of metalloproteins, viz. cytochrome P-450 and ironsulfur proteins are described. The cytochrome P-450 mimic consists of a Mn porphyrin and a Rh complex which are incorporated within a vesicle membrane in water. This system catalyses the reductive activation of molecular oxygen in the epoxidation of alkenes at Mn, with reducing equivalents derived from the simultaneous Rh c...
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ژورنال
عنوان ژورنال: YAKUGAKU ZASSHI
سال: 1965
ISSN: 0031-6903,1347-5231
DOI: 10.1248/yakushi1947.85.7_596